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KMID : 0387420040150010065
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Korean Society of Oriental Neuropsychiatry
2004 Volume.15 No. 1 p.65 ~ p.76
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Study on the regeneratory and inhibitory effect of CT105-induced neuroblastoma cell lines by Hyeolbuchukeo-tang water extract
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Jung Yun-Gwan
Kim Sung-Wook
Gong Dae-Jong
Kim Geun-Woo
Koo Byung-Su
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Abstract
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Alzheimer’s disease(AD) is a geriatric dementia that is widespread in old ages. In the future AD will be the largest problem in public health service. From old times, much medicines have been used for treatment of dementia, but there is no medicine having obvious effects. AD is one of brain retrogression disease. So we studied on herbal medicine that have a relation for brain retrogression. From old times, in oriental medicine, senile disease such as dementia and AD is treated by exclusion of Tan(痰). But Vascular Dementia(VsD) is due to YuXue(瘀血). So in recent studies, Hua Xue Hua Yu(活血化瘀) medicine is used for precautionary and medical treatment. We studied on the effects for anti-Alzheimer in pCT105-induced neuroblastoma cell lines by Hyeolbuchukeo-tang(HCT). As the results of this study, in HCT group, the apoptosis in the nervous system is inhibited, the repair against the degeneration of Neuroblastoma cells by CT105 expression is promoted. These results indicate that HCT possess strong inhibitory effect of apoptosis in the nervous system and repair effect against the degeneration of neuroblastoma cells by CT105 expression.
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KEYWORD
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Hyeolbuchukeo-tang(HCT), Alzheimer’s disease, ${\beta}-amyloid$ precusor protein, carboxyl-terminal 105(CT105)
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